mitkAterialInputFunctionGenerator.h

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/*============================================================================
 
The Medical Imaging Interaction Toolkit (MITK)
 
Copyright (c) German Cancer Research Center (DKFZ)
All rights reserved.
 
Use of this source code is governed by a 3-clause BSD license that can be
found in the LICENSE file.
 
============================================================================*/
 
#ifndef mitkAterialInputFunctionGenerator_h
#define mitkAterialInputFunctionGenerator_h
 
#include <mitkImage.h>
#include "mitkAIFBasedModelBase.h"
#include "MitkPharmacokineticsExports.h"
 
 
namespace mitk
{
  class MITKPHARMACOKINETICS_EXPORT AterialInputFunctionGenerator : public itk::Object
  {
  public:
 
    mitkClassMacroItkParent(AterialInputFunctionGenerator, itk::Object);
    itkNewMacro(Self);
 
    itkSetConstObjectMacro(DynamicImage, Image);
    itkGetConstObjectMacro(DynamicImage, Image);
 
    itkSetConstObjectMacro(Mask, Image);
    itkGetConstObjectMacro(Mask, Image);
 
    itkSetMacro(HCL, double);
    itkGetConstReferenceMacro(HCL, double);
 
    //Common Value for Hematocrit level is 0.45
    static const double DEFAULT_HEMATOCRIT_LEVEL;
 
    void SetDefaultHematocritLevel()
    {
        this->m_HCL = DEFAULT_HEMATOCRIT_LEVEL;
    };
    double GetDefaultHematocritLevel()
    {
        return DEFAULT_HEMATOCRIT_LEVEL;
    }
 
    AIFBasedModelBase::AterialInputFunctionType GetAterialInputFunction();
    ModelBase::TimeGridType GetAterialInputFunctionTimeGrid();
 
  protected:
    AterialInputFunctionGenerator()
    {
      m_Mask = nullptr;
      m_DynamicImage = nullptr;
      this->SetDefaultHematocritLevel();
    };
 
    ~AterialInputFunctionGenerator() override {};
 
    //template <typename TPixel, unsigned int VDim>
    //void DoCalculateAIF(itk::Image<TPixel, VDim>* image);
 
    virtual void CalculateAIFAndGetResult();
 
    virtual void CheckValidInputs() const;
 
    bool HasOutdatedResults();
 
 
    itk::TimeStamp m_GenerationTimeStamp;
 
  private:
    Image::ConstPointer m_DynamicImage;
    Image::ConstPointer m_Mask;
 
 
    AIFBasedModelBase::AterialInputFunctionType m_AIFValues;
    ModelBase::TimeGridType m_AIFTimeGrid;
 
    double m_HCL;
  };
 
}
 
#endif