mitk::TwoCompartmentExchangeModel Class Reference

Implementation of the analystical model function of the Physiological Pharmacokinetic Brix model, using an Aterial Input Function The Model calculates the Concentration-Time-Curve as a convolution of the Aterial Input funciton CA(t) and a tissue specific residue function R(t). The Residue funktion consists of two parts: The Residue funktion Qp(t) of the Blood Plasma p and the residue funktion Qi(t) of the interstitial volume I. Ctotal(t) = vp * Cp(t) + fi * Ci(t) = [vp * Qp(t) + fi * Qi(t)] conv CA(t) = Qtotal(t) conv CA(t) where vp=Vp/VT and fi=Vi/VT are the portion of Plasma/interstitial volume Vp/VI of the total volume VT respectively. The Residuefunctions are described by Qp(t) = F/Vp * PS/Vp * 1/(l2 - l1) [ µ2 exp(l1*t) - µ1 exp(l2*t)] sig(t) Qi(t) = F/Vp * PS/Vi * 1/(l1 - l2) [ exp(l1*t) - exp(l2*t)] sig(t) = F/Vp * PS/Vp * vp/fi * 1/(l1 - l2) [ exp(l1*t) - exp(l2*t)] sig(t) with l1/2 = -1/2 (PS/Vp * vp/fi + PS/Vp + F/Vp) +/- sqrt((PS/Vp * vp/fi + PS/Vp + F/Vp)² - 4* F/Vp * PS/Vp * vp/fi) µ1/2 = F/Vp * Vp/PS + 1 + Vp/PS* l1/2. More...

#include <mitkTwoCompartmentExchangeModel.h>

Inheritance diagram for mitk::TwoCompartmentExchangeModel:

Collaboration diagram for mitk::TwoCompartmentExchangeModel:

Public Types
typedef TwoCompartmentExchangeModel	Self
typedef AIFBasedModelBase	Superclass
typedef itk::SmartPointer< Self >	Pointer
typedef itk::SmartPointer< const Self >	ConstPointer
Public Types inherited from mitk::AIFBasedModelBase
typedef AIFBasedModelBase	Self
typedef ModelBase	Superclass
typedef itk::SmartPointer< Self >	Pointer
typedef itk::SmartPointer< const Self >	ConstPointer
typedef itk::Array< double >	AterialInputFunctionType
Public Types inherited from mitk::ModelBase
typedef ModelBase	Self
typedef itk::Object	Superclass
typedef itk::SmartPointer< Self >	Pointer
typedef itk::SmartPointer< const Self >	ConstPointer
typedef ModelTraitsInterface::ModelResultType	ModelResultType
typedef ModelTraitsInterface::ParameterValueType	ParameterValueType
typedef ModelTraitsInterface::ParametersType	ParametersType
typedef itk::Array< double >	TimeGridType
typedef ModelTraitsInterface::ParameterNameType	ParameterNameType
typedef ModelTraitsInterface::ParameterNamesType	ParameterNamesType
typedef ModelTraitsInterface::ParametersSizeType	ParametersSizeType
typedef ModelTraitsInterface::DerivedParameterNamesType	DerivedParameterNamesType
typedef ModelTraitsInterface::DerivedParametersSizeType	DerivedParametersSizeType
typedef double	StaticParameterValueType
typedef std::vector< StaticParameterValueType >	StaticParameterValuesType
typedef std::map< ParameterNameType, StaticParameterValuesType >	StaticParameterMapType
typedef double	DerivedParameterValueType
typedef std::map< ParameterNameType, DerivedParameterValueType >	DerivedParameterMapType
Public Types inherited from mitk::ModelTraitsInterface
typedef itk::Array< double >	ModelResultType
using	ParameterValueType = double
typedef itk::Array< ParameterValueType >	ParametersType
typedef std::string	ParameterNameType
typedef std::vector< ParameterNameType >	ParameterNamesType
typedef ParametersType::SizeValueType	ParametersSizeType
typedef ParameterNamesType	DerivedParameterNamesType
typedef ParametersSizeType	DerivedParametersSizeType
typedef std::map< ParameterNameType, double >	ParamterScaleMapType
typedef std::map< ParameterNameType, std::string >	ParamterUnitMapType
typedef std::map< ParameterNameType, double >	DerivedParamterScaleMapType
typedef std::map< ParameterNameType, std::string >	DerivedParamterUnitMapType
typedef std::string	FunctionStringType
typedef std::string	ModellClassIDType

Public Member Functions
Pointer	Clone () const
virtual const char *	GetClassName () const
std::string	GetModelDisplayName () const override
std::string	GetModelType () const override
ParameterNamesType	GetParameterNames () const override
ParametersSizeType	GetNumberOfParameters () const override
ParamterUnitMapType	GetParameterUnits () const override
Public Member Functions inherited from mitk::AIFBasedModelBase
virtual const AterialInputFunctionType &	GetAterialInputFunctionValues ()
virtual const TimeGridType &	GetAterialInputFunctionTimeGrid ()
virtual void	SetAterialInputFunctionValues (AterialInputFunctionType _arg)
virtual void	SetAterialInputFunctionTimeGrid (TimeGridType _arg)
std::string	GetXAxisName () const override
std::string	GetXAxisUnit () const override
std::string	GetYAxisName () const override
std::string	GetYAxisUnit () const override
const TimeGridType &	GetCurrentAterialInputFunctionTimeGrid () const
const AterialInputFunctionType	GetAterialInputFunction (TimeGridType currentTimeGrid) const
ParameterNamesType	GetStaticParameterNames () const override
ParametersSizeType	GetNumberOfStaticParameters () const override
ParamterUnitMapType	GetStaticParameterUnits () const override
Public Member Functions inherited from mitk::ModelBase
ParamterScaleMapType	GetParameterScales () const override
DerivedParamterScaleMapType	GetDerivedParameterScales () const override
DerivedParamterUnitMapType	GetDerivedParameterUnits () const override
FunctionStringType	GetFunctionString () const override
ModellClassIDType	GetClassID () const override
std::string	GetXName () const override
DerivedParameterNamesType	GetDerivedParameterNames () const override
DerivedParametersSizeType	GetNumberOfDerivedParameters () const override
void	SetStaticParameters (const StaticParameterMapType &parameters, bool allParameters=true)
StaticParameterMapType	GetStaticParameters () const
DerivedParameterMapType	GetDerivedParameters (const ParametersType &parameters) const
virtual void	SetTimeGrid (const TimeGridType &grid)
virtual const TimeGridType &	GetTimeGrid ()
ModelResultType	GetSignal (const ParametersType &parameters) const

Static Public Member Functions
static Pointer	New ()

Static Public Attributes
static const std::string	NAME_PARAMETER_F
static const std::string	NAME_PARAMETER_PS
static const std::string	NAME_PARAMETER_ve
static const std::string	NAME_PARAMETER_vp
static const unsigned int	POSITION_PARAMETER_F
static const unsigned int	POSITION_PARAMETER_PS
static const unsigned int	POSITION_PARAMETER_ve
static const unsigned int	POSITION_PARAMETER_vp
static const std::string	UNIT_PARAMETER_F
static const std::string	UNIT_PARAMETER_PS
static const std::string	UNIT_PARAMETER_ve
static const std::string	UNIT_PARAMETER_vp
static const unsigned int	NUMBER_OF_PARAMETERS
static const std::string	MODEL_DISPLAY_NAME
static const std::string	MODEL_TYPE
Static Public Attributes inherited from mitk::AIFBasedModelBase
static const std::string	NAME_STATIC_PARAMETER_AIF
static const std::string	NAME_STATIC_PARAMETER_AIFTimeGrid
static const std::string	UNIT_STATIC_PARAMETER_AIF
static const std::string	UNIT_STATIC_PARAMETER_AIFTimeGrid
static const unsigned int	NUMBER_OF_STATIC_PARAMETERS
static const std::string	X_AXIS_NAME
static const std::string	X_AXIS_UNIT
static const std::string	Y_AXIS_NAME
static const std::string	Y_AXIS_UNIT

Protected Member Functions
	TwoCompartmentExchangeModel ()
	~TwoCompartmentExchangeModel () override
itk::LightObject::Pointer	InternalClone () const override
ModelResultType	ComputeModelfunction (const ParametersType &parameters) const override
void	PrintSelf (std::ostream &os, ::itk::Indent indent) const override
Protected Member Functions inherited from mitk::AIFBasedModelBase
	AIFBasedModelBase ()
	~AIFBasedModelBase () override
bool	ValidateModel (std::string &error) const override
void	PrintSelf (std::ostream &os, ::itk::Indent indent) const override
void	SetStaticParameter (const ParameterNameType &name, const StaticParameterValuesType &values) override
StaticParameterValuesType	GetStaticParameterValue (const ParameterNameType &name) const override
Protected Member Functions inherited from mitk::ModelBase
virtual DerivedParameterMapType	ComputeDerivedParameters (const ParametersType &parameters) const
	ModelBase ()
	~ModelBase () override
void	PrintSelf (std::ostream &os, ::itk::Indent indent) const override
Protected Member Functions inherited from mitk::ModelTraitsInterface
	ModelTraitsInterface ()
virtual	~ModelTraitsInterface ()

Additional Inherited Members
Protected Attributes inherited from mitk::AIFBasedModelBase
TimeGridType	m_AterialInputFunctionTimeGrid
AterialInputFunctionType	m_AterialInputFunctionValues
Protected Attributes inherited from mitk::ModelBase
TimeGridType	m_TimeGrid

Detailed Description

Implementation of the analystical model function of the Physiological Pharmacokinetic Brix model, using an Aterial Input Function The Model calculates the Concentration-Time-Curve as a convolution of the Aterial Input funciton CA(t) and a tissue specific residue function R(t). The Residue funktion consists of two parts: The Residue funktion Qp(t) of the Blood Plasma p and the residue funktion Qi(t) of the interstitial volume I. Ctotal(t) = vp * Cp(t) + fi * Ci(t) = [vp * Qp(t) + fi * Qi(t)] conv CA(t) = Qtotal(t) conv CA(t) where vp=Vp/VT and fi=Vi/VT are the portion of Plasma/interstitial volume Vp/VI of the total volume VT respectively. The Residuefunctions are described by Qp(t) = F/Vp * PS/Vp * 1/(l2 - l1) [ µ2 exp(l1*t) - µ1 exp(l2*t)] sig(t) Qi(t) = F/Vp * PS/Vi * 1/(l1 - l2) [ exp(l1*t) - exp(l2*t)] sig(t) = F/Vp * PS/Vp * vp/fi * 1/(l1 - l2) [ exp(l1*t) - exp(l2*t)] sig(t) with l1/2 = -1/2 (PS/Vp * vp/fi + PS/Vp + F/Vp) +/- sqrt((PS/Vp * vp/fi + PS/Vp + F/Vp)² - 4* F/Vp * PS/Vp * vp/fi) µ1/2 = F/Vp * Vp/PS + 1 + Vp/PS* l1/2.

The parameters PS/Vp, F/Vp, vp and fi are subject to the fitting routine

Definition at line 40 of file mitkTwoCompartmentExchangeModel.h.

Member Typedef Documentation

ConstPointer

typedef itk::SmartPointer< const Self > mitk::TwoCompartmentExchangeModel::ConstPointer

Definition at line 47 of file mitkTwoCompartmentExchangeModel.h.

Pointer

typedef itk::SmartPointer< Self > mitk::TwoCompartmentExchangeModel::Pointer

Definition at line 46 of file mitkTwoCompartmentExchangeModel.h.

Self

typedef TwoCompartmentExchangeModel mitk::TwoCompartmentExchangeModel::Self

Definition at line 44 of file mitkTwoCompartmentExchangeModel.h.

Superclass

typedef AIFBasedModelBase mitk::TwoCompartmentExchangeModel::Superclass

Definition at line 45 of file mitkTwoCompartmentExchangeModel.h.

Constructor & Destructor Documentation

TwoCompartmentExchangeModel()

mitk::TwoCompartmentExchangeModel::TwoCompartmentExchangeModel ( )

protected

~TwoCompartmentExchangeModel()

mitk::TwoCompartmentExchangeModel::~TwoCompartmentExchangeModel ( )

overrideprotected

Member Function Documentation

Clone()

Pointer mitk::TwoCompartmentExchangeModel::Clone

(

)

const

ComputeModelfunction()

ModelResultType mitk::TwoCompartmentExchangeModel::ComputeModelfunction ( const ParametersType &  parameters ) const

overrideprotectedvirtual

Implements mitk::ModelBase.

GetClassName()

virtual const char* mitk::TwoCompartmentExchangeModel::GetClassName ( ) const

virtual

Run-time type information (and related methods).

Reimplemented from mitk::AIFBasedModelBase.

GetModelDisplayName()

std::string mitk::TwoCompartmentExchangeModel::GetModelDisplayName ( ) const

overridevirtual

Default implementation returns GetClassID as display name.

Reimplemented from mitk::ModelBase.

GetModelType()

std::string mitk::TwoCompartmentExchangeModel::GetModelType ( ) const

overridevirtual

Default implementation returns "Unkown" as model type.

Reimplemented from mitk::ModelBase.

GetNumberOfParameters()

ParametersSizeType mitk::TwoCompartmentExchangeModel::GetNumberOfParameters ( ) const

overridevirtual

Returns the number of parameters that must be defined when using the model to compute the signal (GetSignal()).

Implements mitk::ModelTraitsInterface.

GetParameterNames()

ParameterNamesType mitk::TwoCompartmentExchangeModel::GetParameterNames ( ) const

overridevirtual

Returns the names of parameters that must be defined when using the model to compute the signal (GetSignal()).

Implements mitk::ModelTraitsInterface.

GetParameterUnits()

ParamterUnitMapType mitk::TwoCompartmentExchangeModel::GetParameterUnits ( ) const

overridevirtual

Default implementation returns no unit string ("") for every defined parameter.

Reimplemented from mitk::ModelBase.

InternalClone()

itk::LightObject::Pointer mitk::TwoCompartmentExchangeModel::InternalClone ( ) const

overrideprotected

Actual implementation of the clone method. This method should be reimplemeted in subclasses to clone the extra required parameters.

New()

static Pointer mitk::TwoCompartmentExchangeModel::New ( )

static

Method for creation through the object factory.

PrintSelf()

void mitk::TwoCompartmentExchangeModel::PrintSelf ( std::ostream &  os, ::itk::Indent  indent  ) const

overrideprotected

Member Data Documentation

MODEL_DISPLAY_NAME

const std::string mitk::TwoCompartmentExchangeModel::MODEL_DISPLAY_NAME

static

Definition at line 75 of file mitkTwoCompartmentExchangeModel.h.

MODEL_TYPE

const std::string mitk::TwoCompartmentExchangeModel::MODEL_TYPE

static

Definition at line 77 of file mitkTwoCompartmentExchangeModel.h.

NAME_PARAMETER_F

const std::string mitk::TwoCompartmentExchangeModel::NAME_PARAMETER_F

static

Model Specifications

Definition at line 54 of file mitkTwoCompartmentExchangeModel.h.

NAME_PARAMETER_PS

const std::string mitk::TwoCompartmentExchangeModel::NAME_PARAMETER_PS

static

Definition at line 59 of file mitkTwoCompartmentExchangeModel.h.

NAME_PARAMETER_ve

const std::string mitk::TwoCompartmentExchangeModel::NAME_PARAMETER_ve

static

Definition at line 60 of file mitkTwoCompartmentExchangeModel.h.

NAME_PARAMETER_vp

const std::string mitk::TwoCompartmentExchangeModel::NAME_PARAMETER_vp

static

Definition at line 61 of file mitkTwoCompartmentExchangeModel.h.

NUMBER_OF_PARAMETERS

const unsigned int mitk::TwoCompartmentExchangeModel::NUMBER_OF_PARAMETERS

static

Definition at line 73 of file mitkTwoCompartmentExchangeModel.h.

POSITION_PARAMETER_F

const unsigned int mitk::TwoCompartmentExchangeModel::POSITION_PARAMETER_F

static

Definition at line 63 of file mitkTwoCompartmentExchangeModel.h.

POSITION_PARAMETER_PS

const unsigned int mitk::TwoCompartmentExchangeModel::POSITION_PARAMETER_PS

static

Definition at line 64 of file mitkTwoCompartmentExchangeModel.h.

POSITION_PARAMETER_ve

const unsigned int mitk::TwoCompartmentExchangeModel::POSITION_PARAMETER_ve

static

Definition at line 65 of file mitkTwoCompartmentExchangeModel.h.

POSITION_PARAMETER_vp

const unsigned int mitk::TwoCompartmentExchangeModel::POSITION_PARAMETER_vp

static

Definition at line 66 of file mitkTwoCompartmentExchangeModel.h.

UNIT_PARAMETER_F

const std::string mitk::TwoCompartmentExchangeModel::UNIT_PARAMETER_F

static

Definition at line 68 of file mitkTwoCompartmentExchangeModel.h.

UNIT_PARAMETER_PS

const std::string mitk::TwoCompartmentExchangeModel::UNIT_PARAMETER_PS

static

Definition at line 69 of file mitkTwoCompartmentExchangeModel.h.

UNIT_PARAMETER_ve

const std::string mitk::TwoCompartmentExchangeModel::UNIT_PARAMETER_ve

static

Definition at line 70 of file mitkTwoCompartmentExchangeModel.h.

UNIT_PARAMETER_vp

const std::string mitk::TwoCompartmentExchangeModel::UNIT_PARAMETER_vp

static

Definition at line 71 of file mitkTwoCompartmentExchangeModel.h.

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The documentation for this class was generated from the following file:

• mitkTwoCompartmentExchangeModel.h