mitk::ExtendedToftsModel Class Reference

Implementation of the Model function of the Tofts pharmacokinetic model, using an Aterial Input Function The Model calculates the Concentration-Time-Curve as a convolution of the plasma curve Cp (the AIF) and a tissue specific residue function (in this case an exponential: R(t) = ktrans * exp(-ktrans/ve * (t)) ). C(t) = vp * Cp(t) + conv(Cp(t),R(t)) The parameters ktrans, ve and ve are subject to the fitting routine. More...

#include <mitkExtendedToftsModel.h>

Inheritance diagram for mitk::ExtendedToftsModel:

Collaboration diagram for mitk::ExtendedToftsModel:

Public Types
typedef ExtendedToftsModel	Self
typedef AIFBasedModelBase	Superclass
typedef itk::SmartPointer< Self >	Pointer
typedef itk::SmartPointer< const Self >	ConstPointer
Public Types inherited from mitk::AIFBasedModelBase
typedef AIFBasedModelBase	Self
typedef ModelBase	Superclass
typedef itk::SmartPointer< Self >	Pointer
typedef itk::SmartPointer< const Self >	ConstPointer
typedef itk::Array< double >	AterialInputFunctionType
Public Types inherited from mitk::ModelBase
typedef ModelBase	Self
typedef itk::Object	Superclass
typedef itk::SmartPointer< Self >	Pointer
typedef itk::SmartPointer< const Self >	ConstPointer
typedef ModelTraitsInterface::ModelResultType	ModelResultType
typedef ModelTraitsInterface::ParameterValueType	ParameterValueType
typedef ModelTraitsInterface::ParametersType	ParametersType
typedef itk::Array< double >	TimeGridType
typedef ModelTraitsInterface::ParameterNameType	ParameterNameType
typedef ModelTraitsInterface::ParameterNamesType	ParameterNamesType
typedef ModelTraitsInterface::ParametersSizeType	ParametersSizeType
typedef ModelTraitsInterface::DerivedParameterNamesType	DerivedParameterNamesType
typedef ModelTraitsInterface::DerivedParametersSizeType	DerivedParametersSizeType
typedef double	StaticParameterValueType
typedef std::vector< StaticParameterValueType >	StaticParameterValuesType
typedef std::map< ParameterNameType, StaticParameterValuesType >	StaticParameterMapType
typedef double	DerivedParameterValueType
typedef std::map< ParameterNameType, DerivedParameterValueType >	DerivedParameterMapType
Public Types inherited from mitk::ModelTraitsInterface
typedef itk::Array< double >	ModelResultType
using	ParameterValueType = double
typedef itk::Array< ParameterValueType >	ParametersType
typedef std::string	ParameterNameType
typedef std::vector< ParameterNameType >	ParameterNamesType
typedef ParametersType::SizeValueType	ParametersSizeType
typedef ParameterNamesType	DerivedParameterNamesType
typedef ParametersSizeType	DerivedParametersSizeType
typedef std::map< ParameterNameType, double >	ParamterScaleMapType
typedef std::map< ParameterNameType, std::string >	ParamterUnitMapType
typedef std::map< ParameterNameType, double >	DerivedParamterScaleMapType
typedef std::map< ParameterNameType, std::string >	DerivedParamterUnitMapType
typedef std::string	FunctionStringType
typedef std::string	ModellClassIDType

Public Member Functions
Pointer	Clone () const
virtual const char *	GetClassName () const
std::string	GetModelDisplayName () const override
std::string	GetModelType () const override
ParameterNamesType	GetParameterNames () const override
ParametersSizeType	GetNumberOfParameters () const override
ParamterUnitMapType	GetParameterUnits () const override
ParameterNamesType	GetDerivedParameterNames () const override
ParametersSizeType	GetNumberOfDerivedParameters () const override
ParamterUnitMapType	GetDerivedParameterUnits () const override
Public Member Functions inherited from mitk::AIFBasedModelBase
virtual const AterialInputFunctionType &	GetAterialInputFunctionValues ()
virtual const TimeGridType &	GetAterialInputFunctionTimeGrid ()
virtual void	SetAterialInputFunctionValues (AterialInputFunctionType _arg)
virtual void	SetAterialInputFunctionTimeGrid (TimeGridType _arg)
std::string	GetXAxisName () const override
std::string	GetXAxisUnit () const override
std::string	GetYAxisName () const override
std::string	GetYAxisUnit () const override
const TimeGridType &	GetCurrentAterialInputFunctionTimeGrid () const
const AterialInputFunctionType	GetAterialInputFunction (TimeGridType currentTimeGrid) const
ParameterNamesType	GetStaticParameterNames () const override
ParametersSizeType	GetNumberOfStaticParameters () const override
ParamterUnitMapType	GetStaticParameterUnits () const override
Public Member Functions inherited from mitk::ModelBase
ParamterScaleMapType	GetParameterScales () const override
DerivedParamterScaleMapType	GetDerivedParameterScales () const override
FunctionStringType	GetFunctionString () const override
ModellClassIDType	GetClassID () const override
std::string	GetXName () const override
void	SetStaticParameters (const StaticParameterMapType &parameters, bool allParameters=true)
StaticParameterMapType	GetStaticParameters () const
DerivedParameterMapType	GetDerivedParameters (const ParametersType &parameters) const
virtual void	SetTimeGrid (const TimeGridType &grid)
virtual const TimeGridType &	GetTimeGrid ()
ModelResultType	GetSignal (const ParametersType &parameters) const

Static Public Member Functions
static Pointer	New ()

Static Public Attributes
static const std::string	NAME_PARAMETER_Ktrans
static const std::string	NAME_PARAMETER_ve
static const std::string	NAME_PARAMETER_vp
static const std::string	UNIT_PARAMETER_Ktrans
static const std::string	UNIT_PARAMETER_ve
static const std::string	UNIT_PARAMETER_vp
static const unsigned int	POSITION_PARAMETER_Ktrans
static const unsigned int	POSITION_PARAMETER_ve
static const unsigned int	POSITION_PARAMETER_vp
static const unsigned int	NUMBER_OF_PARAMETERS
static const std::string	NAME_DERIVED_PARAMETER_kep
static const unsigned int	NUMBER_OF_DERIVED_PARAMETERS
static const std::string	UNIT_DERIVED_PARAMETER_kep
static const std::string	MODEL_DISPLAY_NAME
static const std::string	MODEL_TYPE
Static Public Attributes inherited from mitk::AIFBasedModelBase
static const std::string	NAME_STATIC_PARAMETER_AIF
static const std::string	NAME_STATIC_PARAMETER_AIFTimeGrid
static const std::string	UNIT_STATIC_PARAMETER_AIF
static const std::string	UNIT_STATIC_PARAMETER_AIFTimeGrid
static const unsigned int	NUMBER_OF_STATIC_PARAMETERS
static const std::string	X_AXIS_NAME
static const std::string	X_AXIS_UNIT
static const std::string	Y_AXIS_NAME
static const std::string	Y_AXIS_UNIT

Protected Member Functions
	ExtendedToftsModel ()
	~ExtendedToftsModel () override
itk::LightObject::Pointer	InternalClone () const override
ModelResultType	ComputeModelfunction (const ParametersType &parameters) const override
DerivedParameterMapType	ComputeDerivedParameters (const mitk::ModelBase::ParametersType &parameters) const override
void	PrintSelf (std::ostream &os, ::itk::Indent indent) const override
Protected Member Functions inherited from mitk::AIFBasedModelBase
	AIFBasedModelBase ()
	~AIFBasedModelBase () override
bool	ValidateModel (std::string &error) const override
void	PrintSelf (std::ostream &os, ::itk::Indent indent) const override
void	SetStaticParameter (const ParameterNameType &name, const StaticParameterValuesType &values) override
StaticParameterValuesType	GetStaticParameterValue (const ParameterNameType &name) const override
Protected Member Functions inherited from mitk::ModelBase
	ModelBase ()
	~ModelBase () override
void	PrintSelf (std::ostream &os, ::itk::Indent indent) const override
Protected Member Functions inherited from mitk::ModelTraitsInterface
	ModelTraitsInterface ()
virtual	~ModelTraitsInterface ()

Additional Inherited Members
Protected Attributes inherited from mitk::AIFBasedModelBase
TimeGridType	m_AterialInputFunctionTimeGrid
AterialInputFunctionType	m_AterialInputFunctionValues
Protected Attributes inherited from mitk::ModelBase
TimeGridType	m_TimeGrid

Detailed Description

Implementation of the Model function of the Tofts pharmacokinetic model, using an Aterial Input Function The Model calculates the Concentration-Time-Curve as a convolution of the plasma curve Cp (the AIF) and a tissue specific residue function (in this case an exponential: R(t) = ktrans * exp(-ktrans/ve * (t)) ). C(t) = vp * Cp(t) + conv(Cp(t),R(t)) The parameters ktrans, ve and ve are subject to the fitting routine.

Definition at line 28 of file mitkExtendedToftsModel.h.

Member Typedef Documentation

ConstPointer

typedef itk::SmartPointer< const Self > mitk::ExtendedToftsModel::ConstPointer

Definition at line 35 of file mitkExtendedToftsModel.h.

Pointer

typedef itk::SmartPointer< Self > mitk::ExtendedToftsModel::Pointer

Definition at line 34 of file mitkExtendedToftsModel.h.

Self

typedef ExtendedToftsModel mitk::ExtendedToftsModel::Self

Definition at line 32 of file mitkExtendedToftsModel.h.

Superclass

typedef AIFBasedModelBase mitk::ExtendedToftsModel::Superclass

Definition at line 33 of file mitkExtendedToftsModel.h.

Constructor & Destructor Documentation

ExtendedToftsModel()

mitk::ExtendedToftsModel::ExtendedToftsModel ( )

protected

~ExtendedToftsModel()

mitk::ExtendedToftsModel::~ExtendedToftsModel ( )

overrideprotected

Member Function Documentation

Clone()

Pointer mitk::ExtendedToftsModel::Clone

(

)

const

ComputeDerivedParameters()

DerivedParameterMapType mitk::ExtendedToftsModel::ComputeDerivedParameters ( const mitk::ModelBase::ParametersType &  parameters ) const

overrideprotectedvirtual

Helper function called by GetDerivedParameters(). Implement in derived classes to realize the concrete computation of derived parameters.

Remarks

Default implementation has no derived parameters

Reimplemented from mitk::ModelBase.

ComputeModelfunction()

ModelResultType mitk::ExtendedToftsModel::ComputeModelfunction ( const ParametersType &  parameters ) const

overrideprotectedvirtual

Implements mitk::ModelBase.

GetClassName()

virtual const char* mitk::ExtendedToftsModel::GetClassName ( ) const

virtual

Run-time type information (and related methods).

Reimplemented from mitk::AIFBasedModelBase.

GetDerivedParameterNames()

ParameterNamesType mitk::ExtendedToftsModel::GetDerivedParameterNames ( ) const

overridevirtual

Returns the names of derived parameters that can/will be computed by the model given specific model parameters.

Remarks

Default implementation has no derived parameters

Reimplemented from mitk::ModelBase.

GetDerivedParameterUnits()

ParamterUnitMapType mitk::ExtendedToftsModel::GetDerivedParameterUnits ( ) const

overridevirtual

Default implementation returns no unit string ("") for every defined derived parameter.

Reimplemented from mitk::ModelBase.

GetModelDisplayName()

std::string mitk::ExtendedToftsModel::GetModelDisplayName ( ) const

overridevirtual

Default implementation returns GetClassID as display name.

Reimplemented from mitk::ModelBase.

GetModelType()

std::string mitk::ExtendedToftsModel::GetModelType ( ) const

overridevirtual

Default implementation returns "Unkown" as model type.

Reimplemented from mitk::ModelBase.

GetNumberOfDerivedParameters()

ParametersSizeType mitk::ExtendedToftsModel::GetNumberOfDerivedParameters ( ) const

overridevirtual

Returns the number of derived parameters that can/will be computed by the model given specific model parameters.

Remarks

Default implementation has no derived parameters

Reimplemented from mitk::ModelBase.

GetNumberOfParameters()

ParametersSizeType mitk::ExtendedToftsModel::GetNumberOfParameters ( ) const

overridevirtual

Returns the number of parameters that must be defined when using the model to compute the signal (GetSignal()).

Implements mitk::ModelTraitsInterface.

GetParameterNames()

ParameterNamesType mitk::ExtendedToftsModel::GetParameterNames ( ) const

overridevirtual

Returns the names of parameters that must be defined when using the model to compute the signal (GetSignal()).

Implements mitk::ModelTraitsInterface.

GetParameterUnits()

ParamterUnitMapType mitk::ExtendedToftsModel::GetParameterUnits ( ) const

overridevirtual

Default implementation returns no unit string ("") for every defined parameter.

Reimplemented from mitk::ModelBase.

InternalClone()

itk::LightObject::Pointer mitk::ExtendedToftsModel::InternalClone ( ) const

overrideprotected

Actual implementation of the clone method. This method should be reimplemeted in subclasses to clone the extra required parameters.

New()

static Pointer mitk::ExtendedToftsModel::New ( )

static

Method for creation through the object factory.

PrintSelf()

void mitk::ExtendedToftsModel::PrintSelf ( std::ostream &  os, ::itk::Indent  indent  ) const

overrideprotected

Member Data Documentation

MODEL_DISPLAY_NAME

const std::string mitk::ExtendedToftsModel::MODEL_DISPLAY_NAME

static

Definition at line 64 of file mitkExtendedToftsModel.h.

MODEL_TYPE

const std::string mitk::ExtendedToftsModel::MODEL_TYPE

static

Definition at line 66 of file mitkExtendedToftsModel.h.

NAME_DERIVED_PARAMETER_kep

const std::string mitk::ExtendedToftsModel::NAME_DERIVED_PARAMETER_kep

static

Definition at line 58 of file mitkExtendedToftsModel.h.

NAME_PARAMETER_Ktrans

const std::string mitk::ExtendedToftsModel::NAME_PARAMETER_Ktrans

static

Definition at line 42 of file mitkExtendedToftsModel.h.

NAME_PARAMETER_ve

const std::string mitk::ExtendedToftsModel::NAME_PARAMETER_ve

static

Definition at line 45 of file mitkExtendedToftsModel.h.

NAME_PARAMETER_vp

const std::string mitk::ExtendedToftsModel::NAME_PARAMETER_vp

static

Definition at line 46 of file mitkExtendedToftsModel.h.

NUMBER_OF_DERIVED_PARAMETERS

const unsigned int mitk::ExtendedToftsModel::NUMBER_OF_DERIVED_PARAMETERS

static

Definition at line 60 of file mitkExtendedToftsModel.h.

NUMBER_OF_PARAMETERS

const unsigned int mitk::ExtendedToftsModel::NUMBER_OF_PARAMETERS

static

Definition at line 56 of file mitkExtendedToftsModel.h.

POSITION_PARAMETER_Ktrans

const unsigned int mitk::ExtendedToftsModel::POSITION_PARAMETER_Ktrans

static

Definition at line 52 of file mitkExtendedToftsModel.h.

POSITION_PARAMETER_ve

const unsigned int mitk::ExtendedToftsModel::POSITION_PARAMETER_ve

static

Definition at line 53 of file mitkExtendedToftsModel.h.

POSITION_PARAMETER_vp

const unsigned int mitk::ExtendedToftsModel::POSITION_PARAMETER_vp

static

Definition at line 54 of file mitkExtendedToftsModel.h.

UNIT_DERIVED_PARAMETER_kep

const std::string mitk::ExtendedToftsModel::UNIT_DERIVED_PARAMETER_kep

static

Definition at line 62 of file mitkExtendedToftsModel.h.

UNIT_PARAMETER_Ktrans

const std::string mitk::ExtendedToftsModel::UNIT_PARAMETER_Ktrans

static

Definition at line 48 of file mitkExtendedToftsModel.h.

UNIT_PARAMETER_ve

const std::string mitk::ExtendedToftsModel::UNIT_PARAMETER_ve

static

Definition at line 49 of file mitkExtendedToftsModel.h.

UNIT_PARAMETER_vp

const std::string mitk::ExtendedToftsModel::UNIT_PARAMETER_vp

static

Definition at line 50 of file mitkExtendedToftsModel.h.

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The documentation for this class was generated from the following file:

• mitkExtendedToftsModel.h