Medical Imaging Interaction Toolkit  2018.4.99-389bf124
Medical Imaging Interaction Toolkit
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mitk::OneTissueCompartmentModel Class Reference

Implementation of the Model function of the Tofts pharmacokinetic model, using an Aterial Input Function The Model calculates the Concentration-Time-Curve as a convolution of the plasma curve Cp (the AIF) and a tissue specific residue function (in this case an exponential: R(t) = ktrans * exp(-ktrans/ve * (t)) ). C(t) = vp * Cp(t) + conv(Cp(t),R(t)) The parameters ktrans, ve and ve are subject to the fitting routine. More...

#include <mitkOneTissueCompartmentModel.h>

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Public Types

typedef OneTissueCompartmentModel Self
 
typedef AIFBasedModelBase Superclass
 
typedef itk::SmartPointer< Self > Pointer
 
typedef itk::SmartPointer< const Self > ConstPointer
 
- Public Types inherited from mitk::AIFBasedModelBase
typedef AIFBasedModelBase Self
 
typedef ModelBase Superclass
 
typedef itk::SmartPointer< Self > Pointer
 
typedef itk::SmartPointer< const Self > ConstPointer
 
typedef itk::Array< double > AterialInputFunctionType
 
- Public Types inherited from mitk::ModelBase
typedef ModelBase Self
 
typedef itk::Object Superclass
 
typedef itk::SmartPointer< Self > Pointer
 
typedef itk::SmartPointer< const Self > ConstPointer
 
typedef ModelTraitsInterface::ModelResultType ModelResultType
 
typedef ModelTraitsInterface::ParameterValueType ParameterValueType
 
typedef ModelTraitsInterface::ParametersType ParametersType
 
typedef itk::Array< double > TimeGridType
 
typedef ModelTraitsInterface::ParameterNameType ParameterNameType
 
typedef ModelTraitsInterface::ParameterNamesType ParameterNamesType
 
typedef ModelTraitsInterface::ParametersSizeType ParametersSizeType
 
typedef ModelTraitsInterface::DerivedParameterNamesType DerivedParameterNamesType
 
typedef ModelTraitsInterface::DerivedParametersSizeType DerivedParametersSizeType
 
typedef double StaticParameterValueType
 
typedef std::vector< StaticParameterValueType > StaticParameterValuesType
 
typedef std::map< ParameterNameType, StaticParameterValuesType > StaticParameterMapType
 
typedef double DerivedParameterValueType
 
typedef std::map< ParameterNameType, DerivedParameterValueType > DerivedParameterMapType
 
- Public Types inherited from mitk::ModelTraitsInterface
typedef itk::Array< double > ModelResultType
 
using ParameterValueType = double
 
typedef itk::Array< ParameterValueType > ParametersType
 
typedef std::string ParameterNameType
 
typedef std::vector< ParameterNameType > ParameterNamesType
 
typedef ParametersType::SizeValueType ParametersSizeType
 
typedef ParameterNamesType DerivedParameterNamesType
 
typedef ParametersSizeType DerivedParametersSizeType
 
typedef std::map< ParameterNameType, double > ParamterScaleMapType
 
typedef std::map< ParameterNameType, std::string > ParamterUnitMapType
 
typedef std::map< ParameterNameType, double > DerivedParamterScaleMapType
 
typedef std::map< ParameterNameType, std::string > DerivedParamterUnitMapType
 
typedef std::string FunctionStringType
 
typedef std::string ModellClassIDType
 

Public Member Functions

Pointer Clone () const
 
virtual const char * GetClassName () const
 
std::string GetModelDisplayName () const override
 
std::string GetModelType () const override
 
ParameterNamesType GetParameterNames () const override
 
ParametersSizeType GetNumberOfParameters () const override
 
ParamterUnitMapType GetParameterUnits () const override
 
- Public Member Functions inherited from mitk::AIFBasedModelBase
virtual const AterialInputFunctionType & GetAterialInputFunctionValues ()
 
virtual const TimeGridType & GetAterialInputFunctionTimeGrid ()
 
virtual void SetAterialInputFunctionValues (AterialInputFunctionType _arg)
 
virtual void SetAterialInputFunctionTimeGrid (TimeGridType _arg)
 
std::string GetXAxisName () const override
 
std::string GetXAxisUnit () const override
 
std::string GetYAxisName () const override
 
std::string GetYAxisUnit () const override
 
const TimeGridType & GetCurrentAterialInputFunctionTimeGrid () const
 
const AterialInputFunctionType GetAterialInputFunction (TimeGridType currentTimeGrid) const
 
ParameterNamesType GetStaticParameterNames () const override
 
ParametersSizeType GetNumberOfStaticParameters () const override
 
ParamterUnitMapType GetStaticParameterUnits () const override
 
- Public Member Functions inherited from mitk::ModelBase
ParamterScaleMapType GetParameterScales () const override
 
DerivedParamterScaleMapType GetDerivedParameterScales () const override
 
DerivedParamterUnitMapType GetDerivedParameterUnits () const override
 
FunctionStringType GetFunctionString () const override
 
ModellClassIDType GetClassID () const override
 
std::string GetXName () const override
 
DerivedParameterNamesType GetDerivedParameterNames () const override
 
DerivedParametersSizeType GetNumberOfDerivedParameters () const override
 
void SetStaticParameters (const StaticParameterMapType &parameters, bool allParameters=true)
 
StaticParameterMapType GetStaticParameters () const
 
DerivedParameterMapType GetDerivedParameters (const ParametersType &parameters) const
 
virtual void SetTimeGrid (const TimeGridType &grid)
 
virtual const TimeGridType & GetTimeGrid ()
 
ModelResultType GetSignal (const ParametersType &parameters) const
 

Static Public Member Functions

static Pointer New ()
 

Static Public Attributes

static const std::string MODEL_DISPLAY_NAME
 
static const std::string NAME_PARAMETER_k1
 
static const std::string NAME_PARAMETER_k2
 
static const std::string UNIT_PARAMETER_k1
 
static const std::string UNIT_PARAMETER_k2
 
static const unsigned int POSITION_PARAMETER_k1
 
static const unsigned int POSITION_PARAMETER_k2
 
static const unsigned int NUMBER_OF_PARAMETERS
 
- Static Public Attributes inherited from mitk::AIFBasedModelBase
static const std::string NAME_STATIC_PARAMETER_AIF
 
static const std::string NAME_STATIC_PARAMETER_AIFTimeGrid
 
static const std::string UNIT_STATIC_PARAMETER_AIF
 
static const std::string UNIT_STATIC_PARAMETER_AIFTimeGrid
 

Protected Member Functions

 OneTissueCompartmentModel ()
 
 ~OneTissueCompartmentModel () override
 
itk::LightObject::Pointer InternalClone () const override
 
ModelResultType ComputeModelfunction (const ParametersType &parameters) const override
 
void PrintSelf (std::ostream &os, ::itk::Indent indent) const override
 
- Protected Member Functions inherited from mitk::AIFBasedModelBase
 AIFBasedModelBase ()
 
 ~AIFBasedModelBase () override
 
bool ValidateModel (std::string &error) const override
 
void PrintSelf (std::ostream &os, ::itk::Indent indent) const override
 
void SetStaticParameter (const ParameterNameType &name, const StaticParameterValuesType &values) override
 
StaticParameterValuesType GetStaticParameterValue (const ParameterNameType &name) const override
 
- Protected Member Functions inherited from mitk::ModelBase
virtual DerivedParameterMapType ComputeDerivedParameters (const ParametersType &parameters) const
 
 ModelBase ()
 
 ~ModelBase () override
 
void PrintSelf (std::ostream &os, ::itk::Indent indent) const override
 
- Protected Member Functions inherited from mitk::ModelTraitsInterface
 ModelTraitsInterface ()
 
virtual ~ModelTraitsInterface ()
 

Additional Inherited Members

- Protected Attributes inherited from mitk::AIFBasedModelBase
TimeGridType m_AterialInputFunctionTimeGrid
 
AterialInputFunctionType m_AterialInputFunctionValues
 
- Protected Attributes inherited from mitk::ModelBase
TimeGridType m_TimeGrid
 

Detailed Description

Implementation of the Model function of the Tofts pharmacokinetic model, using an Aterial Input Function The Model calculates the Concentration-Time-Curve as a convolution of the plasma curve Cp (the AIF) and a tissue specific residue function (in this case an exponential: R(t) = ktrans * exp(-ktrans/ve * (t)) ). C(t) = vp * Cp(t) + conv(Cp(t),R(t)) The parameters ktrans, ve and ve are subject to the fitting routine.

Definition at line 28 of file mitkOneTissueCompartmentModel.h.

Member Typedef Documentation

◆ ConstPointer

typedef itk::SmartPointer< const Self > mitk::OneTissueCompartmentModel::ConstPointer

Definition at line 35 of file mitkOneTissueCompartmentModel.h.

◆ Pointer

typedef itk::SmartPointer< Self > mitk::OneTissueCompartmentModel::Pointer

Definition at line 34 of file mitkOneTissueCompartmentModel.h.

◆ Self

typedef OneTissueCompartmentModel mitk::OneTissueCompartmentModel::Self

Definition at line 32 of file mitkOneTissueCompartmentModel.h.

◆ Superclass

typedef AIFBasedModelBase mitk::OneTissueCompartmentModel::Superclass

Definition at line 33 of file mitkOneTissueCompartmentModel.h.

Constructor & Destructor Documentation

◆ OneTissueCompartmentModel()

mitk::OneTissueCompartmentModel::OneTissueCompartmentModel ( )
protected

Definition at line 41 of file mitkOneTissueCompartmentModel.cpp.

◆ ~OneTissueCompartmentModel()

mitk::OneTissueCompartmentModel::~OneTissueCompartmentModel ( )
overrideprotected

Definition at line 46 of file mitkOneTissueCompartmentModel.cpp.

Member Function Documentation

◆ Clone()

Pointer mitk::OneTissueCompartmentModel::Clone ( ) const

◆ ComputeModelfunction()

mitk::OneTissueCompartmentModel::ModelResultType mitk::OneTissueCompartmentModel::ComputeModelfunction ( const ParametersType &  parameters) const
overrideprotectedvirtual

Implements mitk::ModelBase.

Definition at line 79 of file mitkOneTissueCompartmentModel.cpp.

References mitk::convoluteAIFWithExponential(), mitk::AIFBasedModelBase::GetAterialInputFunction(), mitk::ModelBase::m_TimeGrid, POSITION_PARAMETER_k1, and POSITION_PARAMETER_k2.

◆ GetClassName()

virtual const char* mitk::OneTissueCompartmentModel::GetClassName ( ) const
virtual

Run-time type information (and related methods).

Reimplemented from mitk::AIFBasedModelBase.

◆ GetModelDisplayName()

std::string mitk::OneTissueCompartmentModel::GetModelDisplayName ( ) const
overridevirtual

Default implementation returns GetClassID as display name.

Reimplemented from mitk::ModelBase.

Definition at line 31 of file mitkOneTissueCompartmentModel.cpp.

References MODEL_DISPLAY_NAME.

◆ GetModelType()

std::string mitk::OneTissueCompartmentModel::GetModelType ( ) const
overridevirtual

Default implementation returns "Unkown" as model type.

Reimplemented from mitk::ModelBase.

Definition at line 36 of file mitkOneTissueCompartmentModel.cpp.

◆ GetNumberOfParameters()

mitk::OneTissueCompartmentModel::ParametersSizeType mitk::OneTissueCompartmentModel::GetNumberOfParameters ( ) const
overridevirtual

Returns the number of parameters that must be defined when using the model to compute the signal (GetSignal()).

Implements mitk::ModelTraitsInterface.

Definition at line 61 of file mitkOneTissueCompartmentModel.cpp.

References NUMBER_OF_PARAMETERS.

◆ GetParameterNames()

mitk::OneTissueCompartmentModel::ParameterNamesType mitk::OneTissueCompartmentModel::GetParameterNames ( ) const
overridevirtual

Returns the names of parameters that must be defined when using the model to compute the signal (GetSignal()).

Implements mitk::ModelTraitsInterface.

Definition at line 51 of file mitkOneTissueCompartmentModel.cpp.

References NAME_PARAMETER_k1, and NAME_PARAMETER_k2.

◆ GetParameterUnits()

mitk::OneTissueCompartmentModel::ParamterUnitMapType mitk::OneTissueCompartmentModel::GetParameterUnits ( ) const
overridevirtual

Default implementation returns no unit string ("") for every defined parameter.

Reimplemented from mitk::ModelBase.

Definition at line 69 of file mitkOneTissueCompartmentModel.cpp.

References NAME_PARAMETER_k1, NAME_PARAMETER_k2, UNIT_PARAMETER_k1, and UNIT_PARAMETER_k2.

◆ InternalClone()

itk::LightObject::Pointer mitk::OneTissueCompartmentModel::InternalClone ( ) const
overrideprotected

Actual implementation of the clone method. This method should be reimplemeted in subclasses to clone the extra required parameters.

Definition at line 123 of file mitkOneTissueCompartmentModel.cpp.

References mitk::ModelBase::m_TimeGrid, and New().

◆ New()

static Pointer mitk::OneTissueCompartmentModel::New ( )
static

Method for creation through the object factory.

Referenced by InternalClone().

◆ PrintSelf()

void mitk::OneTissueCompartmentModel::PrintSelf ( std::ostream &  os,
::itk::Indent  indent 
) const
overrideprotected

Definition at line 132 of file mitkOneTissueCompartmentModel.cpp.

References mitk::AIFBasedModelBase::PrintSelf().

Member Data Documentation

◆ MODEL_DISPLAY_NAME

const std::string mitk::OneTissueCompartmentModel::MODEL_DISPLAY_NAME
static

Definition at line 42 of file mitkOneTissueCompartmentModel.h.

Referenced by GetModelDisplayName().

◆ NAME_PARAMETER_k1

const std::string mitk::OneTissueCompartmentModel::NAME_PARAMETER_k1
static

Definition at line 46 of file mitkOneTissueCompartmentModel.h.

Referenced by GetParameterNames(), and GetParameterUnits().

◆ NAME_PARAMETER_k2

const std::string mitk::OneTissueCompartmentModel::NAME_PARAMETER_k2
static

Definition at line 47 of file mitkOneTissueCompartmentModel.h.

Referenced by GetParameterNames(), and GetParameterUnits().

◆ NUMBER_OF_PARAMETERS

const unsigned int mitk::OneTissueCompartmentModel::NUMBER_OF_PARAMETERS
static

Definition at line 55 of file mitkOneTissueCompartmentModel.h.

Referenced by GetNumberOfParameters().

◆ POSITION_PARAMETER_k1

const unsigned int mitk::OneTissueCompartmentModel::POSITION_PARAMETER_k1
static

Definition at line 52 of file mitkOneTissueCompartmentModel.h.

Referenced by ComputeModelfunction(), and mitk::OneTissueCompartmentModelParameterizer::GetDefaultInitialParameterization().

◆ POSITION_PARAMETER_k2

const unsigned int mitk::OneTissueCompartmentModel::POSITION_PARAMETER_k2
static

Definition at line 53 of file mitkOneTissueCompartmentModel.h.

Referenced by ComputeModelfunction(), and mitk::OneTissueCompartmentModelParameterizer::GetDefaultInitialParameterization().

◆ UNIT_PARAMETER_k1

const std::string mitk::OneTissueCompartmentModel::UNIT_PARAMETER_k1
static

Definition at line 49 of file mitkOneTissueCompartmentModel.h.

Referenced by GetParameterUnits().

◆ UNIT_PARAMETER_k2

const std::string mitk::OneTissueCompartmentModel::UNIT_PARAMETER_k2
static

Definition at line 50 of file mitkOneTissueCompartmentModel.h.

Referenced by GetParameterUnits().

The documentation for this class was generated from the following files: